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IL31 - Interleukin-31


Did you know that Interleukin-31 is a central mediator of neuroimmune skin dysfunction? IL-31 plays a role in many inflammatory skin diseases, including atopic dermatitis (AD) and prurigo nodularis (PN). 1-3

IL-31 bridges the peripheral nervous system and immune system and targets structural skin cells, driving itch, inflammation, and skin abnormalities. 1 

To learn more about the role of a neuroimmune cytokine in AD and PN, visit


1. Gibbs BF, Patsinakidis N, Raap U. Role of the pruritic cytokine IL-31 in autoimmune skin diseases. Front Immunol. 2019;10:1383. doi:10.3389/fimmu.2019.01383

2. Datsi A, Steinhoff M, Ahmad F, Alam M, Buddenkotte J. Interleukin-31: the “itchy” cytokine in inflammation and therapy. Allergy. 2021;76(10):2982-2997. doi:10.1111/all.14791

3. Williams KA, Roh YS, Brown I, et al. Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis. Expert Rev Clin Pharmacol. 2021;14(1):67-77. doi:10.1080/17512433.2021.1852080


*Expert author(s), speaker(s) or contributor(s) where indicated are paid Galderma consultants.

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